The fungus Aspergillus flavus, previously known for its frightening reputation as the “curse of the pharaohs,” was allegedly responsible for mysterious deaths after the tomb of Tutankhamun was opened. Now scientists from the University of Pennsylvania report that its DNA contains genes responsible for the synthesis of RiPPs—molecules that were able to destroy cancer cells.
Using those compounds, the researchers developed four new peptides, aspergimycins. One of them, after a small modification, showed effectiveness comparable to leading leukemia treatments. At the same time, it practically did not affect healthy cells of other organs, suggesting fewer side effects.
The researchers hope this work will pave the way for an entire class of new anti-cancer drugs derived from natural sources—safe and effective.
